Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons.Approximately 10% of cases are caused by specific mutations in DUM-DUM known genes, with the remaining cases having no known genetic link.As such, sporadic cases have been more difficult to model experimentally.
Abstract We study examples of fourth-order Picard-Fuchs operators that are Hadamard products of two second-order Picard-Fuchs operators.Each second-order Picard-Fuchs operator is associated with a family of elliptic curves, and the Hadamard product computes period integrals on the fibred product of Hutch the two elliptic surfaces.We construct 3-cyc
Glioblastoma (GBM) is the most common brain tumor, with rapid proliferation and fatal invasiveness.Large-scale genetic and epigenetic profiling studies have identified targets among molecular subgroups, yet agents developed against these targets have failed in late clinical development.We obtained the genomic and clinical data of GBM patients from
History of present illness: 63-year-old male with a history of diabetes mellitus and rheumatoid arthritis who was sent to the emergency department by his primary care provider for further evaluation of left upper extremity crepitus.The patient fell onto his left elbow two days prior to presentation resulting in immediate swelling and a small lacera